Recombinant Human CXCL1 Protein (Trx Tag)

The Chemokine (C-X-C motif) Ligand 1, CXCL1, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO?, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-a) . CXCL1 already known to be important in osteoarthritis (OA), as a novel target gene of transcription factor AP-2? in chondrocytes and support the important role of AP-2? in cartilage. CXCL1 is a potent neutrophil chemoattractant with recognized roles in angiogenesis and inflammation. CXCL1 is a novel immediate PTH/PTHrP-responsive gene. CXCL1 may act as a chemoattractant for osteoclast precursors. CXCL1 may also have important pro-nociceptive effects via its direct actions on sensory neurons, and may induce long-term changes that involve protein synthesis. CXCL1 plays a critical nonredundant role in the development of experimental Lyme arthritis and carditis via CXCR2-mediated recruitment of neutrophils into the site of infection. CXCL1 functions through CXCR2 to transactivate the EGFR by proteolytic cleavage of HB-EGF, leading to activation of MAPK signalling and increased proliferation of epithelial ovarian cancer (EOC) cells. It might limit tumor growth by reinforcing senescence early in tumorigenesis. Thus, CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation, wound healing, and tumorigenesis.

CXCL; SCYB; Secretory protein N; CINC; NAP; CXCL1; FSP; GRO1; GROa; MGSA; MGSA-a; NAP-3; SCYB1; GRO alpha; CINC-1; C-X-C Motif Chemokine 1; GRO-A; GRO-Alpha (1-73) ; Growth-Regulated Alpha Protein; GRO-α: MGSAα; Melanoma Growth Stimulatory Activity; NAP3; Neutrophil-Activating Protein 3; Platelet-derived growth factor-inducible protein KC; Secretory protein N51; GRO; alpha; alpha) ; chemokine (C-X-C motif) ligand 1; Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity; C-X-C motif chemokine ligand 1; Cytokine-induced neutrophil chemoattractant 1; Fibroblast secretory protein; Gro 1; Gro A; GRO protein; Gro1 oncogene; GRO1 oncogene (melanoma growth stimulating activity; GRO1 oncogene (melanoma growth-stimulating activity) ; GRO-alpha (6-73) ; homolog of; KC chemokine; melanoma growth stimulatory activity alpha; member 1; MGSA alpha; mouse; N51; Scyb 1; Small inducible cytokine subfamily B

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.