Indapamide-d6
Indapamide-d6 is a deuterated labeled Indapamide[1]. Indapamide is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide is also can reduce left ventricular hypertrophy[2][5].
Product Specifications
UNSPSC
12352005
Target
Isotope-Labeled Compounds; Potassium Channel
Type
Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Cardiovascular Disease
Smiles
O=C(NN1C([2H])(C([2H])([2H])[2H])C([2H])([2H])C2=C1C=CC=C2)C3=CC=C(Cl)C(S(=O)(N)=O)=C3C
Molecular Formula
C17H12D6ClN3O3S
Molecular Weight
385.90
References & Citations
[1]Chaffman, M, et, al. Indapamide. Drugs 28, 189–235 (1984) .|[2]Furman BL, et, al. A further examination of the possible effects of indapamide on glucose tolerance and insulin secretion in the rat and mouse. J Pharm Pharmacol. 1981 Nov;33 (11) :735-7.|[3]Lalande A, et, al. Indapamide, a thiazide-like diuretic, decreases bone resorption in vitro. J Bone Miner Res. 2001 Feb;16 (2) :361-70.|[4]Ma F, et, al. Indapamide lowers blood pressure by increasing production of epoxyeicosatrienoic acids in the kidney. Mol Pharmacol. 2013 Aug;84 (2) :286-95.|[5]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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