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(R) -V-0219 (hydrochloride)

(R) -V-0219 hydrochloride is an enantiomer of V-0219. V-0219 is an orally active and positive allosteric modulator (PAM) of the GLP Receptor-1 (GLP-1R). (R) -V-0219 hydrochloride activates calcium fluxes in HEK cells stably expressing hGLP-1R[1].

Product Specifications

UNSPSC

12352005

Target

GLP Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/r-v-0219-hydrochloride.html

Purity

98.92

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC(C1=CC=C(C2=NOC(CN3C[C@@H](CN4CCOCC4)CCC3)=N2)C=C1)(F)F.[H]Cl

Molecular Formula

C20H26ClF3N4O2

Molecular Weight

446.89

References & Citations

[1]Decara JM, et al. Discovery of V-0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 Receptor toward Oral Treatment for "Diabesity". J Med Chem. 2022 Apr 14;65 (7) :5449-5461.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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