Isofraxidin

Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of ERK1/2 in hepatoma cells[1]. Isofraxidin attenuates the expression of iNOS and COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein-2 (MD-2) complex formation[2].

Product Specifications

CAS Number

[486-21-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

COX; ERK; MMP; Toll-like Receptor (TLR)

Type

Natural Products

Related Pathways

Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/isofraxidin.html

Purity

99.94

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C1C=CC2=CC(OC)=C(O)C(OC)=C2O1

Molecular Formula

C11H10O5

Molecular Weight

222.19

Precautions

H302, H315, H319, H335

References & Citations

[1]Yamazaki T, et al. Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits matrix metalloproteinase-7 expression and cell invasion of human hepatoma cells.Biol Pharm Bull. 2010;33 (10) :1716-22.|[2]Jin J , et al. Isofraxidin targets the TLR4/MD-2 axis to prevent osteoarthritis development.Food Funct. 2018 Nov 14;9 (11) :5641-5652.