Pardoprunox (hydrochloride)

Pardoprunox (SLV-308) hydrochloride is a partial dopamine D2 and D3 receptor partial agonist and a serotonin 5-HT1A receptor agonist, with pEC50s of 8, 9.2, and 6.3, respectively[1].

Product Specifications

CAS Number

[269718-83-4]

Product Name Alternative

SLV-308 hydrochloride; DU-126891 hydrochloride

UNSPSC

12352005

Hazard Statement

H315, H317, H318, H334, H335, H341, H361, H370, H413

Target

5-HT Receptor; Adrenergic Receptor; Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Pardoprunox-hydrochloride.html

Purity

99.46

Solubility

DMSO : 150 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic)

Smiles

O=C1OC2=C(N3CCN(C)CC3)C=CC=C2N1.[H]Cl

Molecular Formula

C12H16ClN3O2

Molecular Weight

269.73

Precautions

H315, H317, H318, H334, H335, H341, H361, H370, H413

References & Citations

[1]Glennon JC, et al. In vitro characterization of SLV308 (7-[4-methyl-1-piperazinyl]-2 (3H) -benzoxazolone, monohydrochloride) : a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist. Synapse. 2006 Dec 15;60 (8) :599-608.|[2]Jones CA, et al. An in vivo pharmacological evaluation of pardoprunox (SLV308) --a novel combined dopamine D (2) /D (3) receptor partial agonist and 5-HT (1A) receptor agonist with efficacy in experimental models of Parkinson's disease. Eur Neuropsychopharmacol. 2010 Aug;20 (8) :582-593.