Sotagliflozin
Sotagliflozin (LX-4211) is a potent dual SGLT2/1 inhibitor. Antidiabetic agents.
Product Specifications
CAS Number
1018899-04-1
Product Name Alternative
LX-4211; LP-802034
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
SGLT
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/LX-4211.html
Purity
99.94
Solubility
DMSO : ≥ 100 mg/mL
Smiles
ClC(C=CC([C@@H]1O[C@H](SC)[C@@H](O)[C@H](O)[C@H]1O)=C2)=C2CC3=CC=C(OCC)C=C3
Molecular Formula
C21H25ClO5S
Molecular Weight
424.94
Precautions
H302, H315, H319, H335
References & Citations
[1]Zambrowicz B, et al. LX4211, a dual SGLT1/SGLT2 inhibitor, improved glycemic control in patients with type 2 diabetes in a randomized, placebo-controlled trial. Clin Pharmacol Ther. 2012 Aug;92 (2) :158-69.|[2]Powell DR, et al. LX4211 increases serum glucagon-like peptide 1 and peptide YY levels by reducing sodium/glucose cotransporter 1 (SGLT1) -mediated absorption of intestinal glucose. J Pharmacol Exp Ther. 2013 May;345 (2) :250-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
SGLT1; SGLT2
Available Sizes
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