(2R,3S) -Azelaprag
(2R,3S) -Azelaprag ((2R,3S) -AMG 986) (Example 238.0) is a precursor of an apelin receptor agonist (EC50=12 nM) and an isomer of Azelaprag (HY-109111) [1].
Product Specifications
CAS Number
[2049979-31-7]
Product Name Alternative
(2R,3S) -AMG 986
UNSPSC
12352005
Target
Apelin Receptor (APJ) ; Drug Isomer
Type
Reference compound
Related Pathways
GPCR/G Protein; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/2r-3s-azelaprag.html
Purity
99.10
Solubility
DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=S(NC1=NN=C(C2=CN=CC(C)=C2)N1C(C(OC)=CC=C3)=C3OC)([C@H](C)[C@H](C4=NC=C(C)C=N4)C)=O
Molecular Formula
C25H29N7O4S
Molecular Weight
523.61
References & Citations
[1]Chen Ning, et al. Triazole agonists of the apj receptor. WO2016187308A1. 2016-11-24.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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