Manogepix

Manogepix (E1210) is a first-in-class, broad-spectrum and orally active antifungal. Manogepix has a mechanism of action-inhibition of fungal glycosylphosphatidylinositol (GPI) biosynthesis[1][2].

Product Specifications

CAS Number

[936339-60-5]

Product Name Alternative

E1210; APX001A

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Fungal

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/manogepix.html

Purity

99.57

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NC1=NC=CC=C1C2=CC(CC3=CC=C(COC4=NC=CC=C4)C=C3)=NO2

Molecular Formula

C21H18N4O2

Molecular Weight

358.39

Precautions

H315, H319, H320

References & Citations

[1]Watanabe NA, et al. E1210, a new broad-spectrum antifungal, suppresses Candida albicans hyphal growth through inhibition of glycosylphosphatidylinositol biosynthesis. Antimicrob Agents Chemother. 2012 Feb;56 (2) :960-71.|[2]Hata K, et al. Efficacy of oral E1210, a new broad-spectrum antifungal with a novel mechanism of action, in murine models of candidiasis, aspergillosis, and fusariosis. Antimicrob Agents Chemother. 2011 Oct;55 (10) :4543-51.