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HL2-m5

HL2-m5 is a potent small molecule inhibitor of the Sonic Hedgehog/PTCH1 interaction, binding Shh with a Kd of 170 nM. It blocks Hedgehog pathway activation and Gli-mediated transcription (IC50 = 230 nM), making it a valuable tool for studying this signaling axis in both cellular and animal models of development and disease.

Product Specifications

Field of Research

Pharmacology & Drug Discovery, Stem Cell & Developmental Biology

Molecular Weight

1632.83

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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