HL2-m5
HL2-m5 is a potent small molecule inhibitor of the Sonic Hedgehog/PTCH1 interaction, binding Shh with a Kd of 170 nM. It blocks Hedgehog pathway activation and Gli-mediated transcription (IC50 = 230 nM), making it a valuable tool for studying this signaling axis in both cellular and animal models of development and disease.
Product Specifications
Field of Research
Pharmacology & Drug Discovery, Stem Cell & Developmental Biology
Molecular Weight
1632.83
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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