NBI-42902
NBI-42902 is an orally active, potent functional and competitive antagonist of GnRH receptor with an IC50 value of 0.79 nM, a Ki value of 0.56 nM, respectively. NBI-42902 inhibits GnRH-stimulated inositol phosphate (IP) accumulation, Ca2+ flux, and ERK1/2 activation. NBI-42902 inhibits serum luteinizing hormone (LH) in castrated male macaques. NBI-42902 can be used for research on sex-hormone-related diseases[1].
Product Specifications
CAS Number
[352290-60-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
GnRH Receptor; PERK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; GPCR/G Protein
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/nbi-42902.html
Concentration
10mM
Purity
98.65
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N(C[C@H](N)C2=CC=CC=C2)C(C(C3=CC=CC(OC)=C3F)=C(C)N1CC4=C(F)C=CC=C4F)=O
Molecular Formula
C27H24F3N3O3
Molecular Weight
495.49
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
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