NBI-42902
Product Specifications
UNSPSC Description
NBI-42902 is an orally active, potent functional and competitive antagonist of GnRH receptor with an IC50 value of 0.79 nM, a Ki value of 0.56 nM, respectively. NBI-42902 inhibits GnRH-stimulated inositol phosphate (IP) accumulation, Ca2+ flux, and ERK1/2 activation. NBI-42902 inhibits serum luteinizing hormone (LH) in castrated male macaques. NBI-42902 can be used for research on sex-hormone-related diseases[1].
Target Antigen
GnRH Receptor; PERK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;GPCR/G Protein
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/nbi-42902.html
Smiles
O=C1N(C[C@H](N)C2=CC=CC=C2)C(C(C3=CC=CC(OC)=C3F)=C(C)N1CC4=C(F)C=CC=C4F)=O
Molecular Weight
495.49
References & Citations
[1]Struthers RS, et al. Pharmacological characterization of a novel nonpeptide antagonist of the human gonadotropin-releasing hormone receptor, NBI-42902. Endocrinology. 2007 Feb;148(2):857-67.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-13699/NBI-42902-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-13699/NBI-42902-SDS-MedChemExpress.pdf
CAS Number
352290-60-9
Available Sizes
Curated Selection
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