Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Olaparib (Standard)

Olaparib (Standard) is the analytical standard of Olaparib. This product is intended for research and analytical applications. Olaparib (AZD2281; KU0059436) is a potent and orally active PARP inhibitor with IC50s of 5 and 1 nM for PARP1 and PARP2, respectively. Olaparib is an autophagy and mitophagy activator[1][2][3][4].

Product Specifications

CAS Number

763113-22-0

Product Name Alternative

AZD2281 (Standard) ; KU0059436 (Standard)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Mitophagy; PARP; Reference Standards

Type

Reference Standards

Related Pathways

Autophagy; Cell Cycle/DNA Damage; Epigenetics; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/olaparib-standard.html

Purity

99.48

Smiles

O=C(C1=CC(CC(C2=C3C=CC=C2)=NNC3=O)=CC=C1F)N4CCN(C(C5CC5)=O)CC4

Molecular Formula

C24H23FN4O3

Molecular Weight

434.46

Precautions

H302, H315, H319, H335

References & Citations

[1]Menear KA, et al. 4-[3- (4-cyclopropanecarbonylpiperazine-1-carbonyl) -4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly (ADP-ribose) polymerase-1. J Med Chem. 2008 Oct 23;51 (20) :6581-91|[2]Senra JM, et al. Inhibition of PARP-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft.Mol Cancer Ther. 2011 Oct;10 (10) :1949-58.|[3]Yasukawa M, et al. Synergetic Effects of PARP Inhibitor AZD2281 in Oral Squamous Cell Carcinoma in Vitro and in Vivo. Int J Mol Sci. 2016 Feb 24;17 (3) :272.|[4]Bian X, et al. PTEN deficiency sensitizes endometrioid endometrial cancer to compound PARP-PI3K inhibition but not PARP inhibition as monotherapy. Oncogene. 2018 Jan 18;37 (3) :341-351.

Shipping Conditions

Room Temperature

Storage Conditions

4°C, sealed storage, away from light and moisture

Scientific Category

Reference Standards

Clinical Information

Launched

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Tissue Genomic DNA, Colon: sigmoid
CD565346 5 µg

Tissue Genomic DNA, Colon: sigmoid

Sign In for Pricing
View Details
IL9R (NM_002186) Human Over-expression Lysate
LY419475 100 µg

IL9R (NM_002186) Human Over-expression Lysate

Sign In for Pricing
View Details
NUBP2 (NM_001284502) Human Tagged ORF Clone
RG236690 10 µg

NUBP2 (NM_001284502) Human Tagged ORF Clone

Sign In for Pricing
View Details
Tissue FFPE Sections, Ovary: left
CS703974 5x 5 µm

Tissue FFPE Sections, Ovary: left

Sign In for Pricing
View Details
RHBDL2 Human Gene Knockout Kit (CRISPR)
KN419882 1 Kit

RHBDL2 Human Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details
IGFBP3 Human Gene Knockout Kit (CRISPR)
KN209150RB 1 Kit

IGFBP3 Human Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details