BP-1-108

BP-1-108 is a selective inhibitor of STAT5 (Ki=8.3 μM) with anticancer activity. BP-1-108 induces apoptosis of leukemia cells by inhibiting the phosphorylation of STAT5. BP-1-108 can be used in the study of acute myeloid leukemia and prostate cancer[1].

Product Specifications

CAS Number

[1334492-85-1]

UNSPSC

12352005

Target

Apoptosis; STAT

Type

Reference compound

Related Pathways

Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bp-1-108.html

Smiles

O=C(O)C1=CC=C(N(CC2=CC=C(C3CCCCC3)C=C2)C(CN(C)S(=O)(C4=C(C)C=C(C)C=C4C)=O)=O)C=C1O

Molecular Formula

C32H38N2O6S

Molecular Weight

578.72

References & Citations

[1]Page, et al. "Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity." Journal of medicinal chemistry 55.3 (2012) : 1047-1055.