BP-1-108
BP-1-108 is a selective inhibitor of STAT5 (Ki=8.3 μM) with anticancer activity. BP-1-108 induces apoptosis of leukemia cells by inhibiting the phosphorylation of STAT5. BP-1-108 can be used in the study of acute myeloid leukemia and prostate cancer[1].
Product Specifications
CAS Number
[1334492-85-1]
UNSPSC
12352005
Target
Apoptosis; STAT
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bp-1-108.html
Smiles
O=C(O)C1=CC=C(N(CC2=CC=C(C3CCCCC3)C=C2)C(CN(C)S(=O)(C4=C(C)C=C(C)C=C4C)=O)=O)C=C1O
Molecular Formula
C32H38N2O6S
Molecular Weight
578.72
References & Citations
[1]Page, et al. "Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity." Journal of medicinal chemistry 55.3 (2012) : 1047-1055.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT5
Curated Selection
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