STL001

STL001 is potent and selective FOXM1 inhibitor. STL001 induces the translocation of nuclear FOXM1 to the cytoplasm and promotes its autophagic degradation. STL001 sensitizes human cancers to a broad-spectrum of cancer therapies[1].

Product Specifications

CAS Number

[3047493-70-6]

UNSPSC

12352005

Target

Autophagy

Type

Reference compound

Related Pathways

Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/stl001.html

Purity

99.81

Solubility

DMSO : 5 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CO1)OC2=CC(C3=NN(C=C3)C4=NC(NC5=CC=CC=C5)=NC(N6CCOCC6)=N4)=CC=C2

Molecular Formula

C27H23N7O4

Molecular Weight

509.52

References & Citations

[1]Sanjeev Raghuwanshi, et al. Novel FOXM1 inhibitor STL001 sensitizes human cancers to a broad-spectrum of cancer therapies. Cell Death Discov. 2024 May 2;10 (1) :211.