Angelic acid

Angelic acid is a ferroptosis inducer, targeting NRF2 degradation. Angelic acid binds to NRF2 protein and promotes NRF2 degradation via ubiquitination-proteasome pathway, relieves the inhibitory effect of NRF2 on oxidative stress and lipid peroxidation. Then, Angelic acid induces ferroptosis in tumor cells. Angelic acid can enhance the accumulation of intracellular reactive oxygen species (ROS), upregulate ferroptosis-related markers CHAC1 and PTGS2, and synergize with ferroptosis inducers to enhance anti-tumor effects. Angelic acid also has the activity of scavenging UVA-induced ROS in vitro, inhibiting skin fibroblast senescence and extracellular matrix degradation. Angelic Acid helps wound healing with sedative activity[1][2].

Product Specifications

CAS Number

[565-63-9]

UNSPSC

12352211

Hazard Statement

H290, H314

Target

Ferroptosis; Keap1-Nrf2; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/angelic-acid.html

Purity

99.20

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

C/C=C(C)\C(O)=O

Molecular Formula

C5H8O2

Molecular Weight

100.12

Precautions

H290, H314

References & Citations

[1]Cao Y, et al. Angelic acid triggers ferroptosis in colorectal cancer cells via targeting and impairing NRF2 protein stability. J Nat Med. 2025 Jan;79 (1) :82-94.|[2]Jung-Eun Ku. Photodamage attenuation effect by angelic acid in UVA irradiation-induced damages in normal human dermal fibroblast. Biomedical Dermatologyvolume 2, Article number: 8 (2018) .