7ACC2

7ACC2 is a potent monocarboxylate transporter (MCT) inhibitor with an IC50 of 11 nM for inhibition of [14C]-lactate influx. 7ACC2 is also a potent inhibitor of mitochondrial pyruvate transport. 7ACC2 is an anticancer agent through inhibition of lactate flux[1][2].

Product Specifications

CAS Number

[1472624-85-3]

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Mitochondrial Metabolism; Monocarboxylate Transporter

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/7ACC2.html

Purity

99.73

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CN(C1=CC=C(C=C(C(O)=O)C(O2)=O)C2=C1)CC3=CC=CC=C3

Molecular Formula

C18H15NO4

Molecular Weight

309.32

Precautions

H302, H312, H332

References & Citations

[1]Draoui N, et al. Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells. Bioorg Med Chem. 2013 Nov 15;21 (22) :7107-17.|[2]Cyril Corbet, et al. Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects. Nat Commun. 2018 Mar 23;9 (1) :1208.