Tucatinib

Tucatinib (Irbinitinib) is a potent, orally active and selective HER2 inhibitor with an IC50 of 8 nM.

Product Specifications

CAS Number

[937263-43-9]

Product Name Alternative

Irbinitinib; ARRY-380; ONT-380

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Irbinitinib.html

Purity

99.87

Solubility

DMSO : 41.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC1=CC(NC2=C3C=C(NC4=NC(C)(C)CO4)C=CC3=NC=N2)=CC=C1OC5=CC6=NC=NN6C=C5

Molecular Formula

C26H24N8O2

Molecular Weight

480.52

Precautions

H302, H315, H319, H335

References & Citations

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

ErbB2/HER2

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

NBP2-59619F 100 µL

Mouse Monoclonal S100B Antibody (S100B/1012) [FITC]

Ask

View Details

RC228409L4V 200 µL

ANKRD33B (NM_001164440) Human Tagged ORF Clone Lentiviral Particle

Ask

View Details

STJ23354 100 µl

Anti-DDB2 antibody

Ask

View Details

TR712664 1 Kit

Svs5 Rat shRNA Plasmid (Locus ID 171027)

Ask

View Details

JOT-AP13114-01 50ul

PKD1(Phospho Tyr463) Polyclonal Antibody

Ask

View Details

JOT-AP13114-02 100ul

PKD1(Phospho Tyr463) Polyclonal Antibody

Ask

View Details