NNC 38-1049
Product Specifications
UNSPSC Description
NNC 38-1049 is an orally active, potent and competitive histamine H3 receptor antagonist. NNC 38-1049 produced an increase in extracellular levels of histamine in the paraventricular nucleus. NNC 38-1049 decreases food intake and body weight, which is promising for research of obesity[1].
Target Antigen
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/nnc-38-1049.html
Purity
99.84
Solubility
DMSO : 6.67 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C(C1=CC=C(Cl)C=C1)CCC(N2CCN(C3CCCC3)CC2)=O
Molecular Weight
348.87
References & Citations
[1]Malmlöf K, et al. Influence of a selective histamine H3 receptor antagonist on hypothalamic neural activity, food intake and body weight. Int J Obes (Lond). 2005 Dec;29(12):1402-12.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-119203/NNC-38-1049-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-119203/NNC-38-1049-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
757183-18-9
Available Sizes
Curated Selection
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