NNC 38-1049

NNC 38-1049 is an orally active, potent and competitive histamine H3 receptor antagonist. NNC 38-1049 produced an increase in extracellular levels of histamine in the paraventricular nucleus. NNC 38-1049 decreases food intake and body weight, which is promising for research of obesity[1].

Product Specifications

CAS Number

[757183-18-9]

UNSPSC

12352005

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/nnc-38-1049.html

Concentration

10mM

Purity

99.84

Solubility

DMSO : 6.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=CC=C(Cl)C=C1)CCC(N2CCN(C3CCCC3)CC2)=O

Molecular Formula

C19H25ClN2O2

Molecular Weight

348.87

References & Citations

[1]Malmlöf K, et al. Influence of a selective histamine H3 receptor antagonist on hypothalamic neural activity, food intake and body weight. Int J Obes (Lond) . 2005 Dec;29 (12) :1402-12.