Myxothiazol

Myxothiazol, an antifungal antibiotic, is a mitochondrial electron transport chain complex III (bc1 complex) inhibitor. Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml[1][2].

Product Specifications

CAS Number

[76706-55-3]

UNSPSC

12352005

Hazard Statement

H300

Target

Antibiotic; Fungal; Mitochondrial Metabolism

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/myxothiazol.html

Purity

99.53

Solubility

DMSO : ≥ 50 mg/mL

Smiles

C[C@H](C1=NC(C2=NC(/C=C/[C@H](OC)[C@@H](C)/C(OC)=C\C(N)=O)=CS2)=CS1)/C=C/C=C/C(C)C

Molecular Formula

C25H33N3O3S2

Molecular Weight

487.68

Precautions

H300

References & Citations

[1]Thierbach G, et al. Myxothiazol, a new antibiotic interfering with respiration. Antimicrob Agents Chemother. 1981;19 (4) :504-507.|[2]von Jagow G, et al. An inhibitor of mitochondrial respiration which binds to cytochrome b and displaces quinone from the iron-sulfur protein of the cytochrome bc1 complex. J Biol Chem. 1984;259 (10) :6318-6326.|[3]Davoudi M, et al. A mouse model of mitochondrial complex III dysfunction induced by myxothiazol. Biochem Biophys Res Commun. 2014;446 (4) :1079-1084.