Indatraline (hydrochloride)

Indatraline hydrochloride (Lu 19-005) is a non-selective monoamine transporter inhibitor that blocks the reuptake of neurotransmitters (dopamine, serotonin, and norepinephrine) . Indatraline hydrochloride can be used for the research of antidepressive. Indatraline hydrochloride induces autophagy while simultaneously inhibiting cell proliferation. Indatraline hydrochloride may also serve to direct the development of new agents for autophagy-related diseases such as atherosclerosis or restenosis[1].

Product Specifications

CAS Number

[96850-13-4]

Product Name Alternative

Lu 19-005

UNSPSC

12352005

Hazard Statement

H410

Target

Dopamine Transporter; Serotonin Transporter

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/indatraline-hydrochloride.html

Purity

99.0

Solubility

10 mM in DMSO

Smiles

CN[C@@H]1C[C@@H](C2=CC=C(Cl)C(Cl)=C2)C3=C1C=CC=C3.[H]Cl

Molecular Formula

C16H16Cl3N

Molecular Weight

328.66

Precautions

H410

References & Citations

[1]Cho YS, et al. Antidepressant indatraline induces autophagy and inhibits restenosis via suppression of mTOR/S6 kinase signaling pathway. Sci Rep. 2016; 6:34655.