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PHGDH-inactive

PHGDH-inactive has no activity against PHGDH and serves as a negative control of NCT-502 and NCT-503[1].

Product Specifications

CAS Number

1914971-16-6

UNSPSC

12352005

Hazard Statement

H315

Target

Phosphoglycerate Dehydrogenase (PHGDH)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/phgdh-inactive.html

Concentration

10mM

Purity

99.93

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

S=C(NC1=NC(C)=CC(C)=C1)N2CCN(CC2)C3=CC=NC=C3

Molecular Formula

C17H21N5S

Molecular Weight

327.45

Precautions

H315

References & Citations

[1]Pacold ME, et al. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate [published correction appears in Nat Chem Biol. 2016 Jul 19;12 (8) :656]. Nat Chem Biol. 2016;12 (6) :452-458.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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