PHGDH-inactive
PHGDH-inactive has no activity against PHGDH and serves as a negative control of NCT-502 and NCT-503[1].
Product Specifications
CAS Number
[1914971-16-6]
UNSPSC
12352005
Hazard Statement
H315
Target
Phosphoglycerate Dehydrogenase (PHGDH)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/phgdh-inactive.html
Concentration
10mM
Purity
99.93
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
S=C(NC1=NC(C)=CC(C)=C1)N2CCN(CC2)C3=CC=NC=C3
Molecular Formula
C17H21N5S
Molecular Weight
327.45
Precautions
H315
References & Citations
[1]Pacold ME, et al. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate [published correction appears in Nat Chem Biol. 2016 Jul 19;12 (8) :656]. Nat Chem Biol. 2016;12 (6) :452-458.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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