inS3-54-A26
Product Specifications
Product Name Alternative
EPZ015866; GSK3203591
UNSPSC Description
inS3-54-A26 is a STAT3 inhibitor. inS3-54-A26 has a toxic IC50 of 4.0 μM for non-cancerous lung fibroblasts[1].
Target Antigen
STAT
Type
Reference compound
Related Pathways
JAK/STAT Signaling;Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ins3-54-a26.html
Solubility
10 mM in DMSO
Smiles
CC(NC1=CC=C(C=C1)N2C(/C(C=C2C3=CC=CC=C3)=C\C4=CC=C(C=C4)Cl)=O)=O
Molecular Weight
414.88
References & Citations
[1]Huang W, et al. Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo. Oncogene. 2016 Feb 11;35(6):783-92.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-118081/inS3-54-A26-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-118081/
Clinical Information
No Development Reported
CAS Number
328998-77-2
Available Sizes
Curated Selection
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