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InS3-54-A26

InS3-54-A26 is a STAT3 inhibitor. inS3-54-A26 has a toxic IC50 of 4.0 μM for non-cancerous lung fibroblasts[1].

Product Specifications

CAS Number

[328998-77-2]

Product Name Alternative

EPZ015866; GSK3203591

UNSPSC

12352005

Target

STAT

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ins3-54-a26.html

Solubility

10 mM in DMSO

Smiles

CC(NC1=CC=C(C=C1)N2C(/C(C=C2C3=CC=CC=C3)=C\C4=CC=C(C=C4)Cl)=O)=O

Molecular Formula

C25H19ClN2O2

Molecular Weight

414.88

References & Citations

[1]Huang W, et al. Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo. Oncogene. 2016 Feb 11;35 (6) :783-92.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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