InS3-54-A26

InS3-54-A26 is a STAT3 inhibitor. inS3-54-A26 has a toxic IC50 of 4.0 μM for non-cancerous lung fibroblasts[1].

Product Specifications

CAS Number

[328998-77-2]

Product Name Alternative

EPZ015866; GSK3203591

UNSPSC

12352005

Target

STAT

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ins3-54-a26.html

Solubility

10 mM in DMSO

Smiles

CC(NC1=CC=C(C=C1)N2C(/C(C=C2C3=CC=CC=C3)=C\C4=CC=C(C=C4)Cl)=O)=O

Molecular Formula

C25H19ClN2O2

Molecular Weight

414.88

References & Citations

[1]Huang W, et al. Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo. Oncogene. 2016 Feb 11;35 (6) :783-92.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

RC227216L4 10 µg

PPIAL4C (NM_001135789) Human Tagged Lenti ORF Clone

Ask

View Details

39533116 3x 1.0 µg

Rhox10 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat)

Ask

View Details

MBS7091018 Inquire

Recombinant Pseudomonas syringae pv. tomato ATP synthase subunit b (atpF), partial

Ask

View Details

ABC-X3445 1 Vial

Xpress™ Human WHAMM Over-expressing Stable Cell Line

Ask

View Details

MBS488220-01 0.2 mg

Anti-CD34 [My10]

Ask

View Details

MBS488220-02 5x 0.2 mg

Anti-CD34 [My10]

Ask

View Details