Bucumolol (hydrochloride)

Bucumolol hydrochloride is a β-adrenergic receptor antagonist that can slow heart rate (negative chronotropic effect) and reduce cardiac contractility (negative inotropic effect) . Bucumolol hydrochloride has antiarrhythmic and local anesthetic activity and can be used in the study of cardiovascular diseases[1].

Product Specifications

CAS Number

[36556-75-9]

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/bucumolol-hydrochloride.html

Smiles

O=C1C=CC2=C(C=CC(OCC(CNC(C)(C)C)O)=C2O1)C.Cl

Molecular Formula

C17H24ClNO4

Molecular Weight

341.83

References & Citations

[1]Nakayama, Koichi, et al. Antiarrhythmic activity of dextro-and levo-isomers OF 5-methyl-8- (2-hydroxy-3-t-butylamino-propoxy) coumarin hydrochloride (bucumolol), a β-adrenergic blocking agent, on aconitine-induced atrial and ouabain-induced ventricular arrhythmias in dogs. The Japanese Journal of Pharmacology 29.6 (1979) : 935-945.