N-Nitrosonornicotine
N-Nitrosonornicotine is a tobacco-specific nitrosamine that has carcinogenic and mutagenic activity, and it can induce micronuclei in C3A cells. N-Nitrosonornicotine can form DNA adducts[1][2].
Product Specifications
CAS Number
16543-55-8
Product Name Alternative
(2S) -N'-Nitrosonornicotine
UNSPSC
12352005
Hazard Statement
H301, H350
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/n-nitrosonornicotine.html
Purity
99.97
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=NN1[C@H](C2=CN=CC=C2)CCC1
Molecular Formula
C9H11N3O
Molecular Weight
177.20
Precautions
H301, H350
References & Citations
[1]Yijing Chen, et al. Metabolism-dependent mutagenicity of two structurally similar tobacco-specific nitrosamines (N-nitrosonornicotine and N-nitrosoanabasine) in human cells, partially different CYPs being activating enzymes. Toxicology. 2024 May:504:153774.|[2]Shugo Suzuki, et al. Cotinine, a major nicotine metabolite, induces cell proliferation on urothelium in vitro and in vivo. Toxicology. 2020 Jan 15:429:152325.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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