N-Nitrosonornicotine

N-Nitrosonornicotine is a tobacco-specific nitrosamine that has carcinogenic and mutagenic activity, and it can induce micronuclei in C3A cells. N-Nitrosonornicotine can form DNA adducts[1][2].

Product Specifications

CAS Number

[16543-55-8]

Product Name Alternative

(2S) -N'-Nitrosonornicotine

UNSPSC

12352005

Hazard Statement

H301, H350

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-nitrosonornicotine.html

Purity

99.97

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

O=NN1[C@H](C2=CN=CC=C2)CCC1

Molecular Formula

C9H11N3O

Molecular Weight

177.20

Precautions

H301, H350

References & Citations

[1]Yijing Chen, et al. Metabolism-dependent mutagenicity of two structurally similar tobacco-specific nitrosamines (N-nitrosonornicotine and N-nitrosoanabasine) in human cells, partially different CYPs being activating enzymes. Toxicology. 2024 May:504:153774.|[2]Shugo Suzuki, et al. Cotinine, a major nicotine metabolite, induces cell proliferation on urothelium in vitro and in vivo. Toxicology. 2020 Jan 15:429:152325.