7BIO
7BIO (7-Bromoindirubin-3-Oxime) is the derivate of indirubin. 7BIO (7-Bromoindirubin-3-Oxime) has inhibitory effects against cyclin-dependent kinase-5 (CDK5) and glycogen synthase kinase-3β (GSK3β) . 7BIO (7-Bromoindirubin-3-Oxime) inhibits Aβ oligomer-induced neuroinflammation, synaptic impairments, tau hyper-phosphorylation, activation of astrocytes and microglia, and attenuates Aβ oligomer-induced cognitive impairments in mice[1].
Product Specifications
CAS Number
916440-85-2
Product Name Alternative
7-Bromoindirubin-3-Oxime
UNSPSC
12352005
Hazard Statement
H228, H315, H319
Target
CDK; GSK-3
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/7bio.html
Purity
99.20
Solubility
DMSO : 250 mg/mL (ultrasonic) |Ethanol : 50 mg/mL (ultrasonic)
Smiles
O/N=C1C2=CC=CC=C2NC\1=C3C(NC4=C(C=CC=C4/3)Br)=O
Molecular Formula
C16H10BrN3O2
Molecular Weight
356.17
Precautions
H228, H315, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK5; GSK-3β
Available Sizes
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