7BIO

7BIO (7-Bromoindirubin-3-Oxime) is the derivate of indirubin. 7BIO (7-Bromoindirubin-3-Oxime) has inhibitory effects against cyclin-dependent kinase-5 (CDK5) and glycogen synthase kinase-3β (GSK3β) . 7BIO (7-Bromoindirubin-3-Oxime) inhibits Aβ oligomer-induced neuroinflammation, synaptic impairments, tau hyper-phosphorylation, activation of astrocytes and microglia, and attenuates Aβ oligomer-induced cognitive impairments in mice[1].

Product Specifications

CAS Number

916440-85-2

Product Name Alternative

7-Bromoindirubin-3-Oxime

UNSPSC

12352005

Hazard Statement

H228, H315, H319

Target

CDK; GSK-3

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/7bio.html

Purity

99.20

Solubility

DMSO : 250 mg/mL (ultrasonic) |Ethanol : 50 mg/mL (ultrasonic)

Smiles

O/N=C1C2=CC=CC=C2NC\1=C3C(NC4=C(C=CC=C4/3)Br)=O

Molecular Formula

C16H10BrN3O2

Molecular Weight

356.17

Precautions

H228, H315, H319

References & Citations

[1] Chen L, et al. Indirubin Derivative 7-Bromoindirubin-3-Oxime (7Bio) Attenuates Aβ Oligomer-Induced Cognitive Impairments in Mice. Front Mol Neurosci. 2017;10:393.