UCPH-101

UCPH-101 is an excitatory amino acid transporter subtype 1 (EAAT1) inhibitor with an IC50 of 0.66 μM.

Product Specifications

CAS Number

1118460-77-7

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

EAAT

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/UCPH-101.html

Purity

98.61

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O=C(C1)C2=C(OC(N)=C(C#N)C2C3=CC=C(OC)C=C3)CC1C4=CC=CC5=C4C=CC=C5

Molecular Formula

C27H22N2O3

Molecular Weight

422.48

Precautions

H302, H315, H319, H335

References & Citations

[1]Abrahamsen B, et al. Allosteric modulation of an excitatory amino acid transporter: the subtype-selective inhibitor UCPH-101 exerts sustained inhibition of EAAT1 through an intramonomeric site in the trimerization domain. J Neurosci. 2013 Jan 16;33 (3) :1068-87.