DFMTI
Product Specifications
UNSPSC Description
DFMTI can completely block the rmGlu1 L757V glutamate response.
In vitro: DFMTI can completely block the rmGlu1 L757V glutamate response, although significantly higher concentrations were required to induce blockade.
In vivo: DFMTI is efficacious in disrupting prepulse inhibition when dosed orally in rats. DFMTI exhibits a moderate decrease in human potency of approximately 3-fold when compared to rat, exemplified by DFMTI.
Target Antigen
mGluR
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/DFMTI.html
Purity
99.04
Solubility
DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C(N(C(C)C)C1)C2=C1C=C(C3=C(C)N(C4=CC=C(F)C=C4F)N=N3)C=C2
Molecular Weight
368.38
References & Citations
[1]Eric D Hostetler, et al. Synthesis, Characterization, and Monkey PET Studies of [<sup>18</sup>F]MK-1312, a PET Tracer for Quantification of mGluR1 Receptor Occupancy by MK-5435. Synapse. 2011 Feb;65(2):125-35.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-100404/DFMTI-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-100404/DFMTI-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
864864-86-8
Available Sizes
Curated Selection
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