Trifluralin-d14

Trifluralin-d14 is the deuterium labeled Trifluralin. Trifluralin is a selective, preemergence, soil-applied herbicide providing control of many important annual grass and broadleaf weed species. Trifluralin prevents weed growth by inhibiting root development through the interruption of mitosis. Trifluralin binds to tubulin and results in the failure of spindle apparatus and cell plate formation. Trifluralin inhibits radicle development on roots. Trifluralin inhibits cell mitosis. Trifluralin is considered to be neurotoxic and haematotoxic[1][2][3][4].

Product Specifications

CAS Number

[347841-79-6]

UNSPSC

12352005

Hazard Statement

H302, H317, H331, H351, H410

Target

Isotope-Labeled Compounds; Microtubule/Tubulin

Type

Isotope-Labeled Compounds

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Others

Field of Research

Others

Concentration

286.23 μM * 1.2 mL in Nonane

Purity

98.0

Solubility

10 mM in DMSO

Smiles

FC(C1=CC([N+]([O-])=O)=C(N(C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])C([N+]([O-])=O)=C1)(F)F

Molecular Formula

C13H2D14F3N3O4

Molecular Weight

349.37

Precautions

H302, H317, H331, H351, H410

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Grover, R., et al., (1997) . Environmental fate of trifluralin. Reviews of environmental contamination and toxicology, 153, 1–64.|[3]C. Fernandes, et al., (2013) . Characterization, Modes of Action and Effects of Trifluralin: A Review. InTech.|[4]Ebert, E., et al., (1992) . Toxicology and hazard potential of trifluralin. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 30 (12), 1031–1044.|[5]Poleksić, V., & Karan, V. (1999) . Effects of trifluralin on carp: biochemical and histological evaluation. Ecotoxicology and environmental safety, 43 (2), 213–221.