Meloside A

Meloside A (Isovitexin 2''-O-glucoside) is a phenylpropanoid found in barley with antioxidant activity. Meloside A can inhibit cell apoptosis and ROS production. Meloside A can inhibit androgen receptor (AR) nuclear translocation and AR protein expression. Meloside A can reduce IL-6, TGF-β1 and DKK-1 levels. Meloside A can be used for the researches of inflammation and endocrinology, such as hair loss[1].

Product Specifications

CAS Number

[60767-80-8]

Product Name Alternative

Isovitexin 2''-O-glucoside; Isovitexin 2''-O-β-D-glucoside

UNSPSC

12352005

Target

Androgen Receptor; Apoptosis; Interleukin Related; Reactive Oxygen Species (ROS) ; TGF-β Receptor

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; TGF-beta/Smad; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Endocrinology; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/meloside-a.html

Purity

98.55

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C=C(C2=CC=C(O)C=C2)OC3=CC(O)=C([C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O[C@H]5[C@@H]([C@H]([C@@H]([C@@H](CO)O5)O)O)O)C(O)=C13

Molecular Formula

C27H30O15

Molecular Weight

594.52

References & Citations

[1]Park HJ, et al. Meloside A Protects Dermal Papilla Cells from DHT-Induced Damage via Androgen Receptor Modulation. Curr Issues Mol Biol. 2025 Jun 9;47 (6) :436.