Rhodiosin

Rhodiosin is a double inhibitor of CYP2D6 and AChE, and can be isolated from Rhodiolis rhodiolis root. The IC50 for CYP2D6 is 0.761 μM, and the Ki is 0.769 μM. Rhodiosin has antioxidant and neuroprotective activity and can regulate HIF-1α signaling pathway to protect the central nervous system[1][2][3][4]

[1]Xu W, et al. Two potent cytochrome P450 2D6 inhibitors found in <i>Rhodiola rosea</i>. Pharmazie. 2013 Dec;68(12):974-6.|[2]Li FJ, et al. Molecular interaction studies of acetylcholinesterase with potential acetylcholinesterase inhibitors from the root of <i>Rhodiola crenulata</i> using molecular docking and isothermal titration calorimetry methods. Int J Biol Macromol. 2017 Nov;104(Pt A):527-532.|[3]Yan X, et al. Salidroside orchestrates metabolic reprogramming by regulating the Hif-1α signalling pathway in acute mountain sickness. Pharm Biol. 2021 Dec;59(1):1540-1550.|[4]Kwon H J, et al. Rhodiosin, an antioxidant flavonol glycoside from Rhodiola rosea. Journal of the Korean Society for Applied Biological Chemistry, 2009, 52: 486-492