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Pomalidomide-C2-amido- (C1-O-C5-O-C1) 2-COOH

Selected Variant

HY-128848-01

Size: 5 mg

Pomalidomide-C2-amido- (C1-O-C5-O-C1) 2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.

Product Specifications

CAS Number

2351103-63-2

Product Name Alternative

Cereblon Ligand-Linker Conjugates 14; E3 ligase Ligand-Linker Conjugates 49

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/e3-ligase-ligand-linker-conjugates-49.html

Purity

95.02

Solubility

DMSO : 55 mg/mL (ultrasonic)

Smiles

O=C(NC1=O)CCC1N(C2=O)C(C3=C2C(NCCNC(COCCCCCOCCOCCCCCOCC(O)=O)=O)=CC=C3)=O

Molecular Formula

C31H44N4O11

Molecular Weight

648.70

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins withPicomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61 (2) :462-481.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Cereblon

Available Sizes

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