Cathepsin G Inhibitor I

Cathepsin G Inhibitor I (compound 7) is an effective, selective, reversible, competitive, non-peptide cathepsin G inhibitor (IC50=53 nM; Ki=63 nM) [1].

Product Specifications

CAS Number

[429676-93-7]

UNSPSC

12352005

Target

Cathepsin

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cathepsin-g-inhibitor-i.html

Concentration

10mM

Purity

99.0

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=C(C(N(C2CCN(C(C3=CC=CC=C3)=O)CC2)C)=O)C=C4C=CC=CC4=C1)C(P(O)(O)=O)C5=C6C=CC=CC6=CC=C5

Molecular Formula

C36H33N2O6P

Molecular Weight

620.63

References & Citations

[1]Greco MN, et al. Nonpeptide inhibitors of cathepsin G: optimization of a novel beta-ketophosphonic acid lead by structure-based drug design. J Am Chem Soc. 2002 Apr 17;124 (15) :3810-1.