AZ32
AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of IC50 of 0.31 μM for ATM in cell.
Product Specifications
CAS Number
2288709-96-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ATM/ATR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AZ32.html
Concentration
10mM
Purity
99.94
Solubility
DMSO : ≥ 150 mg/mL
Smiles
O=C(NC)C(C=C1)=CC=C1C2=CN=C3C=NC(C4=CC=CC=C4)=CN32
Molecular Formula
C20H16N4O
Molecular Weight
328.37
Precautions
H302, H315, H319, H335
References & Citations
[1]Karlin J, et al. Orally Bioavailable and Blood-Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice. Mol Cancer Ther. 2018 Aug;17 (8) :1637-1647.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ATM
Available Sizes
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