TP0586532

TP0586532 is a non-hydroxamate LpxC inhibitor (IC50=0.101 μM) . TP0586532 as a compound with a low cardiovascular risk that is effective against K. pneumoniae, including resistant strains[1]. TP0586532 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[2427584-96-9]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/tp0586532.html

Purity

99.86

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C[C@H](O)C1=NC=CN1CC2=NOC(C(C=C3)=CC=C3C#C[C@H]4[C@@]5([H])[C@]4([H])CN(C5)CCCC(O)=O)=C2

Molecular Formula

C26H28N4O4

Molecular Weight

460.52

Precautions

H315, H319, H335

References & Citations

[1]Ushiyama F, et al. Lead optimization of 2-hydroxymethyl imidazoles as non-hydroxamate LpxC inhibitors: Discovery of TP0586532. Bioorg Med Chem. 2021;30:115964.