KDM4-IN-2

KDM4-IN-2 (Compound 19a) is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively[1].

Product Specifications

CAS Number

[2369607-62-3]

UNSPSC

12352005

Target

Histone Demethylase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/kdm4-in-2.html

Purity

98.29

Solubility

DMSO : 4 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C2=CC=NC(N3C=C(CCN4CCC5(CCC6=C5C=CC=C6)CC4)C=N3)=C2N=CN1

Molecular Formula

C25H26N6O

Molecular Weight

426.51

References & Citations

[1]Le Bihan YV, et al. C8-substituted pyrido[3,4-d]pyrimidin-4 (3H) -ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays. Eur J Med Chem. 2019 Sep 1;177:316-337.