CP 339818 (hydrochloride)

CP 339818 hydrochloride is a non-peptide Kv1.3 channel (IC50 = 200 nM) and Kv1.4 channel blocker. CP 339818 hydrochloride inhibits HCN channel with IC50s of 18.9 μM and 43.4 μM against HCN1 and HCN4 (high Cl-) . CP 339818 hydrochloride has significantly weaker blocking effects on Kv1.1, Kv1.2, Kv1.5, Kv1.6, Kv3.1-4, and Kv4.2 channels. CP 339818 hydrochloride selectively blocked Kv1.3, thereby inhibiting the activation process of human T cells. CP 339818 hydrochloride can be used to study the physiological functions of HCN and Kv channels[1][2][3].

Product Specifications

CAS Number

[478341-55-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

HCN Channel; Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cp-339818-hydrochloride.html

Purity

99.61

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

CCCCC/N=C1C=CN(CC2=CC=CC=C2)C3=C\1C=CC=C3.Cl

Molecular Formula

C21H25ClN2

Molecular Weight

340.89

Precautions

H302, H315, H319

References & Citations

[1]A Nguyen, et al. Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation. Mol Pharmacol. 1996 Dec;50 (6) :1672-9.|[2]Jacobson DA, et al. Calcium-activated and voltage-gated potassium channels of the pancreatic islet impart distinct and complementary roles during secretagogue induced electrical responses. J Physiol. 2010 Sep 15;588 (Pt 18) :3525-37. |[3]Lee YT, et al. Novel pharmacological activity of loperamide and CP-339,818 on human HCN channels characterized with an automated electrophysiology assay. Eur J Pharmacol. 2008 Feb 26;581 (1-2) :97-104.