Erythrabyssin II
Erythrabyssin II (EL-19) is a potent late-stage autophagy inhibitor that blocks the fusion of autophagosome and lysosome. Erythrabyssin II leads to the accumulation of autophagic substrates and does not impair lysosomal pH or lysosomal enzyme activity. Erythrabyssin II suppresses ovarian cancer organoid activity and induces apoptosis. Erythrabyssin II can be used for the study of ovarian cancer[1].
Product Specifications
CAS Number
77263-06-0
UNSPSC
12352005
Target
Apoptosis; Autophagy
Type
Natural Products
Related Pathways
Apoptosis; Autophagy
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/erythrabyssin-ii.html
Solubility
10 mM in DMSO
Smiles
OC1=C(C/C=C(C)\C)C=C2[C@@](OC3=C(C/C=C(C)\C)C(O)=CC=C34)([H])[C@@]4([H])COC2=C1
Molecular Formula
C25H28O4
Molecular Weight
392.49
References & Citations
[1]Jing Mo, et al. Erythrabyssin II is identified as a novel late-stage autophagy inhibitor that reverses chemoresistance and promotes apoptosis in ovarian cancer. ISCIENCE (2025) .
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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