Dacinostat

Dacinostat is a potent HDAC inhibitor, with an IC50 of 32 nM; Dacinostat also inhibits HDAC1 with an IC50 of 9 nM, and used in cancer research.

Product Specifications

CAS Number

[404951-53-7]

Product Name Alternative

NVP-LAQ824; LAQ824

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; HDAC

Type

Reference compound

Related Pathways

Autophagy; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Dacinostat.html

Purity

98.45

Solubility

DMSO : ≥ 43 mg/mL

Smiles

O=C(NO)/C=C/C1=CC=C(CN(CCO)CCC2=CNC3=C2C=CC=C3)C=C1

Molecular Formula

C22H25N3O3

Molecular Weight

379.45

Precautions

H302, H315, H319, H335

References & Citations

[1]Atadja P, et al. Selective growth inhibition of tumor cells by a novel histone deacetylase inhibitor, NVP-LAQ824. Cancer Res. 2004 Jan 15;64 (2) :689-95.|[2]Cho YS, et al. Conformational refinement of hydroxamate-based histone deacetylase inhibitors and exploration of 3-piperidin-3-ylindole analogues of dacinostat (LAQ824) . J Med Chem. 2010 Apr 8;53 (7) :2952-63.|[3]Romanski A, et al. Deacetylase inhibitors modulate proliferation and self-renewal properties of leukemic stem and progenitor cells. Cell Cycle. 2012 Sep 1;11 (17) :3219-26.