Dacinostat
Dacinostat is a potent HDAC inhibitor, with an IC50 of 32 nM; Dacinostat also inhibits HDAC1 with an IC50 of 9 nM, and used in cancer research.
Product Specifications
CAS Number
[404951-53-7]
Product Name Alternative
NVP-LAQ824; LAQ824
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; HDAC
Type
Reference compound
Related Pathways
Autophagy; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Dacinostat.html
Purity
98.45
Solubility
DMSO : ≥ 43 mg/mL
Smiles
O=C(NO)/C=C/C1=CC=C(CN(CCO)CCC2=CNC3=C2C=CC=C3)C=C1
Molecular Formula
C22H25N3O3
Molecular Weight
379.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Atadja P, et al. Selective growth inhibition of tumor cells by a novel histone deacetylase inhibitor, NVP-LAQ824. Cancer Res. 2004 Jan 15;64 (2) :689-95.|[2]Cho YS, et al. Conformational refinement of hydroxamate-based histone deacetylase inhibitors and exploration of 3-piperidin-3-ylindole analogues of dacinostat (LAQ824) . J Med Chem. 2010 Apr 8;53 (7) :2952-63.|[3]Romanski A, et al. Deacetylase inhibitors modulate proliferation and self-renewal properties of leukemic stem and progenitor cells. Cell Cycle. 2012 Sep 1;11 (17) :3219-26.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
HDAC; HDAC1
Available Sizes
Curated Selection
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