TRAF-STOP inhibitor 6877002

TRAF-STOP inhibitor 6877002 is a selective CD40-TRAF6 interaction inhibitor. TRAF-STOP inhibitor 6877002 exerts anti-atherosclerotic activity by blocking the CD40-TRAF6 signaling pathway, inhibiting classical monocyte activation, leukocyte recruitment, and macrophage activation and migration. TRAF-STOP inhibitor 6877002 reduces the phosphorylation levels of signaling intermediates in the canonical NF-κB pathway[1].

Product Specifications

CAS Number

[433249-94-6]

UNSPSC

12352005

Hazard Statement

H411

Target

NF-κB; TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis; NF-κB

Applications

Neuroscience-Neurodegeneration

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/traf-stop-inhibitor-6877002.html

Purity

99.67

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CC=C1)/C=C/NC2=C(C=CC(C)=C2)C

Molecular Formula

C17H17NO

Molecular Weight

251.32

Precautions

H411

References & Citations

[1]Seijkens TTP, et al. Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis. J Am Coll Cardiol. 2018 Feb 6;71 (5) :527-542.|[2]Esther Lutgens, et al. Inhibitors of cd40-traf6 interaction. WO2014033122A1. 2013-08-27