HPK1-IN-7

HPK1-IN-7 is a potent, orally active HPK1 (hematopoietic progenitor kinase 1, MAP4K1) inhibitor (IC50=2.6 nM) with excellent family and kinome selectivity. HPK1-IN-7 shows selectivity against IRAK4 (59 nM) and GLK (140 nM) . HPK1-IN-7 shows robust efficacy against MC38 syngeneic tumor model in combination with anti-PD1[1].

Product Specifications

CAS Number

[2320462-65-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MAP4K

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hpk1-in-7.html

Purity

99.33

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1OC(C)(C)C2=C1C=CC(NC3=NC=C(C4=NN=CO4)C(N[C@@H](C5=CC=CC=C5)CO)=N3)=C2

Molecular Formula

C24H22N6O4

Molecular Weight

458.47

Precautions

H302, H315, H319, H335

References & Citations

[1]Degnan AP, et al. Discovery of Orally Active Isofuranones as Potent, Selective Inhibitors of Hematopoetic Progenitor Kinase 1. ACS Med Chem Lett. 2021;12 (3) :443-450. Published 2021 Feb 19.