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SR-3677

Product Specifications

UNSPSC Description

SR-3677 is a potent and selective ROCK-II inhibitor with an IC50 of ~3 nM.

Target Antigen

Autophagy; ROCK

Type

Reference compound

Related Pathways

Autophagy;Cell Cycle/DNA Damage;Cytoskeleton;Stem Cell/Wnt;TGF-beta/Smad

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/SR-3677.html

Smiles

CN(C)CCOC1=C(NC(C2OC(C=CC=C3)=C3OC2)=O)C=CC(C4=CNN=C4)=C1

Molecular Weight

408.45

References & Citations

[1]Feng Y, et al. Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors. J Med Chem. 2008 Nov 13;51(21):6642-5.

Shipping Conditions

Room Temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-13300/SR-3677-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-13300/SR-3677-SDS-MedChemExpress.pdf

CAS Number

1072959-67-1

Available Sizes

Curated Selection

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