SR-3677
SR-3677 is a potent and selective ROCK-II inhibitor with an IC50 of ~3 nM.
Product Specifications
CAS Number
[1072959-67-1]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Autophagy; ROCK
Type
Reference compound
Related Pathways
Autophagy; Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SR-3677.html
Purity
99.83
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN(C)CCOC1=C(NC(C2OC(C=CC=C3)=C3OC2)=O)C=CC(C4=CNN=C4)=C1
Molecular Formula
C22H24N4O4
Molecular Weight
408.45
Precautions
H315, H319, H335
References & Citations
[1]Feng Y, et al. Discovery of substituted 4- (pyrazol-4-yl) -phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors. J Med Chem. 2008 Nov 13;51 (21) :6642-5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ROCK1; ROCK2
Available Sizes
Curated Selection
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